From biomass to medicines

A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

Indolo[3,2-c]quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.

 

Graphical abstract: From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

 

 

One thought on “From biomass to medicines

  • 26/07/2012 at 22:35
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    This reminded me: A few years back some ±23 patent applications were submitted for furfural-based active compounds for anti retro viral drugs.

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